Answer: No. The Audio Weaver Standard version GUI is a Windows application that runs without MATLAB. With Standard you can design systems, build them, tune in real-time, profile, and ship products.
If you are a MATLAB user then you should consider getting Audio Weaver Developer or Pro versions. These enhanced versions add a MATLAB automation interface which allows you to easily exchange data between MATLAB and Audio Weaver, enabling scripting and regression testing. The MATLAB interface is recommended only for advanced users.